碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究

doi:10.3969/j.issn.1004-616x.2002.02.009

癌变·畸变·突变 ›› 2002, Vol. 14 ›› Issue (2): 98-101.doi: 10.3969/j.issn.1004-616x.2002.02.009

碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究

罗　鹏1;张爱华1;李　军1;岑笃才2;任渝江2;张碧霞2;汪希兰1;黄晓欣2

1. 贵阳医学院预防医学系卫生毒理教研室,贵州　贵阳　550004; 2. 解放军第44 医院肿瘤科,贵州　贵阳　550009

收稿日期:2001-04-23 修回日期:2001-10-22 出版日期:2002-04-30 发布日期:2002-04-30
通讯作者: 罗　鹏

INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

LUO Peng1; ZHANG Ai-hua1; LI Jun1, QING Du-cai2; REN Yu-jiang1; ZHAGN Bi-xia2; WANG Xi-lan1;HUANG Xiao-xing2

1. Dept. of Preventive Medicine, Guiyang Medical College, Guiyang 550004 , China; 2.44th Hospital of PLA, Guiyang 550009, China

Received:2001-04-23 Revised:2001-10-22 Online:2002-04-30 Published:2002-04-30
Contact: LUO Peng

摘要/Abstract

摘要： 目的:探讨碳酸锂(Li2CO3) 对放化疗肿瘤患者有无抗遗传及抗氧化损伤作用。方法:给予临床放化疗肿瘤患者Li2CO3联合用药治疗,采用单细胞凝胶电泳试验、外周血淋巴细胞微核试验及生化试验方法测定DNA 损伤、微核率(MNF) 、超氧化物歧化酶(SOD) 和谷胱苷肽过氧化物酶( GSH-Px) 活力、疏基(2SH) 和丙二醛(MDA) 含量。结果:随Li2CO3 疗程及剂量的增加,联合用药组与单纯放化疗组相比DNA 断裂分级、慧星尾长、MNF 显著降低( P < 0. 05) ; SOD、GSH-Px 活力、2SH 含量、WBC 总数显著增高( P < 0. 01) 。结论:Li2CO3 可降低肿瘤患者遗传损伤程度,提高其抗氧化酶活性,降低抗癌药物的骨髓抑制作用。

关键词: 碳酸锂, 肿瘤患者, 淋巴细胞, 遗传损伤, 氧化损伤,

Abstract: Purpose : To observe the inhibitory effect of lithium carbonate (Li2CO3 ) on genetic and oxidative damage in cancer patients. Methods : The single cell gel elect rophoresis assay (SCGE) , micronucleus test were used to measure DNA and chromosomal damage. At the same time , SOD , GSH-Px , and2SH and MDA were detected by biochemical tests. Results : The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li2CO3 treatment , and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion : Li2CO3 can inhibit genetic damage , increase the ability of anti-oxidation and relieve the myellogenic inhibition.

Key words: lithium carbonate, cancer patient, lymphocyte, genetic damage, oxidation damage

中图分类号:

R73 - 36

罗　鹏, 张爱华, 李　军, 岑笃才, 任渝江, 张碧霞, 汪希兰, 黄晓欣. 碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究[J]. 癌变·畸变·突变, 2002, 14(2): 98-101.

LUO Peng, ZHANG Ai-hua, LI Jun, QING Du-cai, REN Yu-jiang, ZHAGN Bi-xia, WANG Xi-lan, HUANG Xiao-xing. INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(2): 98-101.

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碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究

INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

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